Searchable abstracts of presentations at key conferences in endocrinology

ea0081p123 | Endocrine-Related Cancer | ECE2022

The transcriptomic and methylomic landscape of POU1F1 pituitary tumors

Silva Roman Gloria Elena , Salazar Ma Isabel , Taniguchi Ponciano Keiko , Pena Martinez Juan Eduardo , Vela Patino Sandra , Andonegui Elguera Sergio , Gomez Apo Erick , Macias Laura Chavez , Espinosa Cardenas Etual , Ramirez Renteria Claudia , Ferreira Hermosillo Aldo , Sosa Ernesto , Mercado Moises , Marrero-Rodriguez Daniel

Pituitary adenomas (PA) are primarily benign lesions with monoclonal origins from the adenohypophyseal cells and represent 10-15% of all intracranial tumors. Tumors derived from POU1F1 cell lineage are GH-, TSH-, and PRL-secreting tumors that cause important syndromes such as acromegaly, hyperthyroidism, and sexual dysfunction, respectively. Surgical resection is the first line of treatment; the secondary treatment is pharmacological; despite having targets pharmacological in ...